2021.10.22 23:01 Past-Dog-6144 What questions would you like to ask a time traveler from 100 years in the future?
2021.10.22 23:01 Professor_Toke (Selling) Dozens of Disney/Marvel splits as well as plenty of other cheap HD and 4K titles (including Bourne Supremacy 4K for $3.30, Avengers 4-Movie HD Collection for $9, 600 DMI points for $5)
2021.10.22 23:01 sharewithme Word of The Hour: रंग लगा
2021.10.22 23:01 enghassanfayed Viscosity control drilling fluid additives For Water-Based Mud Commercial clays additives are used to control the viscosity of water-based drilling fluid. These are graded according to their yield. The yield of clay is defined as the number of barrels of 15 centipoise viscosity mud which can be
2021.10.22 23:01 jersele 2 pc crimson 2 pc noblesse better?
2021.10.22 23:01 GanjaG I thought this was so interesting!
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2021.10.22 23:01 Mystik_Palace How plausible would it be for every single Redditor who ever walked the face of the planet to agree with every single idea that you have regardless of their current beliefs and to love you extremely dearly?
2021.10.22 23:01 sl00f Mobile Payment Apps (i.e. Venmo, Zelle) - 18+ Users who use them
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2021.10.22 23:01 sharewithme Word of The Hour: decora
2021.10.22 23:01 breakingasia In U.S.-China Standoff, Is America a Reliable Ally?
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2021.10.22 23:01 Henry_in_Space Day 22 - Open
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2021.10.22 23:01 DogNail Rip apart my draft for CTEV - any criticism helps
Earlier studies found no correlation between smoking and CTEV development. Cardy et. al. had conducted a meta analysis of 785 children with idiopathic CTEV. The authors found that “repots of associates between foot deformities, including CTEV, and maternal smoking during pregnancy are inconsistent” (4). Cardy et. al. “found no evidence of any interaction between family history and maternal (or paternal) smoking” (4). The Candy et.al study was published in 2011 and I think it would be a mistake to exclude smoking as a potential cause of CTEV. Multiple recent studies have concluded that smoking may contribute to the development of CTEV in conjunction with congenital predisposition.
Recently it has been widely accepted that “clubfoot is multifactorial on origin, genetic factors clearly play a central role” (6). A study Bacino et.al supports the notion that smoking in conjunction with congenital malformation result in higher likelihood of CTEV. The study states that “heritability for clubfoot is estimated at 72%” (1). The same study found that “the concordance of CTEV among monozygotic twins is approximately 33% in comparison to 3% in dizygotic twins” (1). The article does acknowledge that smoking metabolism “were explored by studying SNPs in xenobiotic genes as they may increase susceptibility to clubfoot” and “may contribute to clubfoot”. The article acknowledges that smoking “is a strong environmental factor contributing to CTEV”. Overall, “CTEV is the result of interaction of multiple genes/developmental processes and environmental teratogens”. The article focuses on a multifactorial cause of CTEV rather than strictly smoking. The same sentiment was echoed by Smythe et. al. who’s publication pooled data from 1960-2015 with 13,962,989 children in 20 countries. Smythe et.al recognizes “risk factors such as smoking and maternal diabetes” are associated with CTEV but “a multifactorial etiologic model that involves both environment and genetic factors is likely” (5). A recent study conducted in 2021 looked at the annual number of newborns with congenital clubfoot born in Sicily from 1991 to 2004 with a total of 827 cases. Pavone et. al. demonstrated a total of 26 out of 827 cases in Sicily are linked to maternal smoking. Pavone et. al. data analysis indicated an odds ratio “(OR) of 2.0 with smoking and 5.4 with familial history, were found to be independent predictors of clubfoot” (6). Even though, the odds ratio is leaning toward a higher incidence of CTEV associated with congenital etiology the study does acknowledge “maternal smoking, and familial history of clubfoot were statistically significant” (6). The proposed etiology of smoking associated with development of CTEV is linked to vascular disruption resulting in fetal hypoxemia. However, smoking has steadily decreased in the last 20 years while congenital malformation associated with CTEV have been stagnant or increasing. A meta data study Bacino et. al. found that “prevalence of smoking during pregnancy decreased from 9.2% in 2010 to 6.9% in 2017” (2). On the other hand, congenital relative incidence have increased. A 19 year cohort study evaluated incidence of trisomy 21, 13, 18. As mentioned in the lecture trisomy 13 and 18 are associated with development of CTEV. Loane et. al. found “the rise in average maternal age over time has brought with it an increase in the number of pregnancies affects by trisomies 21, 18, 13” (7). In conclusion, incidence of smoking have steadily decrease while maternal age has steadily increase. This leads me to believe that congenital malformation is the main relative risk factor associated with CTEV.
1) Bacino, C. A., & Hecht, J. T. (2014). Etiopathogenesis of equinovarus foot malformations. European Journal of Medical Genetics, 57(8), 473–479. https://doi.org/10.1016/j.ejmg.2014.06.001
2) Azagba, S., Manzione, L., Shan, L., & King, J. (2020, January 23). Trends in smoking during pregnancy by socioeconomic characteristics in the United States, 2010–2017. BMC Pregnancy and Childbirth. Retrieved October 22, 2021, from https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-020-2748-y.
3) Home. Global Clubfoot Initiative. (n.d.). Retrieved October 22, 2021, from https://globalclubfoot.com/clubfoot/.
4) Cardy, A. H., Sharp, L., Torrance, N., Hennekam, R. C., & Miedzybrodzka, Z. (2011). Is there evidence for aetiologically distinct subgroups of idiopathic congenital talipes equinovarus? A case-only study and Pedigree Analysis. PLoS ONE, 6(4). https://doi.org/10.1371/journal.pone.0017895
5)Smythe, T., Kuper, H., Macleod, D., Foster, A., & Lavy, C. (2017). Birth prevalence of congenital talipes equinovarus in low- and middle-income countries: A systematic review and meta-analysis. Tropical Medicine & International Health, 22(3), 269–285. https://doi.org/10.1111/tmi.12833
6)Pavone, V., Bianca, S., Grosso, G., Pavone, P., Mistretta, A., Longo, M. R., Marino, S., & Sessa, G. (2012, June). CONGENITAL TALIPES EQUINOVARUS: An epidemiological study in Sicily. Acta orthopaedica. Retrieved October 23, 2021, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369158/.
7) Loane, M., Dolk, H., & Morris, J. (2011). Total & livebirth prevalence of down syndrome and other trisomies in Europe 1990-2007: Impact of increasing maternal age, prenatal screening and termination of pregnancy. Pediatric Research, 70, 85–85. https://doi.org/10.1038/pr.2011.310
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2021.10.22 23:01 future_dead_guy_ [28M] Bladder always full, frequent urination.
Been to urgent care recently and the ER as well due to having a full sensation in the bladder with a burning sensation that fluctuates in pain in my groin area. I have a weak flow that also fluctuates to OK to dribbling. Both visits they said they had no idea what was going on due to my urine being completely clean. I’m becoming a little distressed because I having a hard time sleeping at night and can barely focus during the day. I’m not entirely sure what to do to alleviate the symptoms while I wait to schedule in to see a urologist. It’s been over 6 days of this. Any suggestions what I should do or keep in mind for the future visit?
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2021.10.22 23:01 sigridstavanger total drama: war crimes
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2021.10.22 23:01 MajorRasta Alice vs Asuna Anime Mash up Battle [youtube]
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2021.10.22 23:01 reddit_feed_bot MRCTV: Are You Ready For 'The Mother of All Caravans'?
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2021.10.22 23:01 Bot-alex Budget 2021: English city regions to get £6.9bn for public transport
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2021.10.22 23:01 DEMIANBARRIENTOS A los que bajaron de peso, cual fue la razón?
2021.10.22 23:01 Acmion The Liberalization of Taxation
In most, if not all, contemporary political systems of today the general population does not get to make direct decisions affecting government spending. However, in, for example, representative democracies the population can try to affect the government spending by voting on representatives that promise to enact certain policies.
The issue here is that the elected representatives rarely keep their promises, either by the virtue of certain policies not being popular enough or due to some other circumstances. One potential fix to this problem is the liberalization of taxation.
To illustrate the meaning of the liberalization of taxation I will give some examples that should be relatively easy to understand.
You work a job that pays $500 per month and the tax rate is 20%. The government decides on what to spend your tax dollars on and you have no say in the matter. As such the following situation arises:
2021.10.22 23:01 sharewithme Word of The Hour: koristella
2021.10.22 23:01 alt-account-J Murder Of The Universe download code up for grabs!
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2021.10.22 23:01 xXdark12Xx Public Last Life SMP, 13+ Mature, 2hr sessions, flexible with time zones, Proximity Chat, 1.17.1 [vanilla]
Public Last Life is a 13+ mature, community with the semi-hardcore plugin known as "Last life" or 3rd life season 2 sessions are 2 hours long on saturdays from 2:30pm to 4:30pm EST (gmt-5) but this can change around and be on different days if needed, Simple voice chat is required but you dont have to use it, you just need to have it installed for you to join the world, join our discord for more info on the server, session times and more, we hope to see you there :D ->https://discord.gg/UBZmqUd957
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2021.10.22 23:01 ben81PRO Pentagon Corrects Defense Secretary on China, Taiwan After White House Fixes Biden Remarks
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2021.10.22 23:01 KyligtWoW | 🧠❤️IQEQ Decentralized Autonomous Think-Thank Organization | Dimaond Launch on 2000 TG Members | No Ownership + Low Tax & MCAP Launch | 90% of token supply in LP | 🧠❤️DYOR for once! |
Shiba Inu & Dogecoin style launch
🔜There are loads of shitcoins and supposed fair launches that are scams! We wanted to create a true Diamond launch, where 90% of the supply is in LP, the token is community driven, where each token represents 1 vote in the future DAO VOTEBOARD. 🧠❤️IQEQ Token is a decentralized autonomous organization & think-thank, to evolve and develop the future of Intelligence and emotional quota through DAO & dAPPs.
Intelligence Quota (IQ) = To know how! Emotional Quota (EQ) = To know yourself!
We do not intend to predict the future! But we know for a certainty that this project will continue and grow!
🌘 $IQEQ token Distribution and information Total Supply: 100 000 000 (100%) Put into LP: 90 000 000 (90%) Development & Marketing wallet: 10 000 000 (10%) Transaction Tax: 5% Rewards: 1% to Holder, 2% to Burn, 2% to LP Launch Market Cap: Under 1000$ Network: Binance Smart Chain DEX: PancakeSwap V2 Preferred trading places > 1. DexTools Exchange 2. Bogged Finance 3. PancakeSwap Exchange
🐋 Anti Whale & Anti Dump During initial 10-15 minutes there will be Max Transaction limit of 0.1% of the Total Supply. Meaning MAX 100 000 $IQEQ tokens to be bought,sold or transferred. This gives everyone a fair chance to enter, and whales & bots have to make MORE trades to enter, at higher entry prices. The team will make sure the launch is successful and that everything is working fine, before turning on Liquidity pool 2% Tax and change/remove the Max Transaction limit of 0.1% before renunciation of contract ownership.
💎Wen Diamond Launch? 🚀 Wen CG? Wen CMC? Wen lambo? More details about this Diamond Launch please!
We will do the fair launch once we fill like the hype is built up enough and we have sufficient amount of members & future holders to eventually grow into a massive hype. Thats our short-term 30 day goals.
1️⃣🌗 Phase one - $50K Market Cap & 250 Holders 👉🏻Contract renunciation & Burn or lock initial LP🟢 👉🏻🛠Start DexTools trending🟢 👉🏻CoinMarketCap Application🟢 👉🏻CoinGecko Application🟢 👉🏻Nomics, WorldCoinIndex & LiveCoinWatch Applications🟢 👉🏻More payed advertising 🟢 👉🏻PooCoin, CoinSniper, CoinVote, CoinHunt, WatcherGuru, RugFreeTokens, IcoHolder, Bitcointalk, Reddit CMS🟢
Check the other 5 phases of our Road Map on our website! [ https://iqeqtoken.com/ ] 💙 IT TAKES LESS THAN 1 MINUTE! ❤️
** OFFICIAL LINKS & CONTACT DETIALS **
** WEBSITE ** [ https://iqeqtoken.com/ ] ** TELEGRAM ** [https://t.me/IQEQToken]
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2021.10.22 23:01 Puzzled_Donkey999 Four pages of a Kaplata info sheet have been completed, more are on their way